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Cell-Free DNA in Pediatric Solid Organ Transplantation Using a New Detection Method of Separating Donor-Derived from Recipient Cell-Free DNA.

Clinical chemistry - 1 Oct 2020

Preka Evgenia, Ellershaw Drew, Chandler Natalie, Ahlfors Helena, Spencer Helen, Chitty Lyn S, Fenton Matthew J, Marks Stephen D

Abstract excerpt

BACKGROUND: The use of cell-free DNA (cfDNA) as a noninvasive biomarker to detect allograft damage is expanding rapidly. However, quantifying the low fraction of donor-derived cfDNA (ddcfDNA) is challenging and requires a highly sensitive technique. ddcfDNA detection through unique donor single nucleotide polymorphisms (SNPs) is a recent new approach, however there are limited data in pediatric solid organ...

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PMID: 32882007
DOI: 10.1093/clinchem/hvaa173

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