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Article

Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD

1 Aug 2020

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) manifests pathological changes in motor neurons and various other cell types. Compared to motor neurons, the contribution of the other cell types to the ALS phenotypes is understudied. G4C2 repeat expansion in C9ORF72 is the most common genetic cause of ALS along with frontotemporal dementia (C9-ALS/FTD), with increasing evidence supporting repeat-encoded poly(GR) in disease...

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PMID: 32755582
DOI: 10.1016/j.celrep.2020.107989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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