Article
Development of a recombinant chimeric Newcastle disease virus-vectored vaccine conferring single-dose, triple protection against genotype VII NDV, IBDV, and H9N2 AIV.
Poultry science - 1 Jul 2026
Yang Panpan, Xiang Mengjia, Tian Kaiyue, Xu Minghe, Zhu Yutao, Qiu Luyao, Xu Muran, Zhang Bingjie, Zhang Yaru, Qiu Jin, Yang Dongdong, Qiao Qilong, Cong Yanfang, Wang Baiyu, Li Jianli, Zhao Jun
Abstract excerpt
Newcastle disease, infectious bursal disease, and H9N2 avian influenza critically threaten the poultry industry worldwide. To achieve single-dose protection against all three pathogens, a recombinant chimeric Newcastle disease virus (NDV) vector vaccine was developed using a genotype-matched strategy. The fusion and hemagglutinin-neuraminidase genes of the LaSota vaccine strain were replaced with those from a...
Topics
- Animals
- Newcastle disease virus
- Influenza A Virus, H9N2 Subtype
- Newcastle Disease
- Chickens
- Viral Vaccines
- Poultry Diseases
- Influenza in Birds
- Infectious bursal disease virus