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Article

Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2007

Siddappa Ramakrishnaiah, Licht Ruud, van Blitterswijk Clemens, de Boer Jan

Abstract excerpt

The use of multipotent human mesenchymal stem cells (hMSCs) for tissue engineering has been a subject of extensive research. The donor variation in growth, differentiation and in vivo bone forming ability of hMSCs is a bottleneck for standardization of therapeutic protocols. In this study, we isolated and characterized hMSCs from 19 independent donors, aged between 27 and 85 years, and investigated the extent of...

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Identifiers

PMID: 17469183
DOI: 10.1002/jor.20402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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