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Targeting epigenetic DNA and histone modifications to treat kidney disease

9 Jan 2018

Abstract excerpt

Epigenetics refers to heritable changes in gene expression patterns not caused by an altered nucleotide sequence, and includes non-coding RNAs and covalent modifications of DNA and histones. This review focuses on functional evidence for the involvement of DNA and histone epigenetic modifications in the pathogenesis of kidney disease and the potential therapeutic implications. There is evidence of activation of...

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Share to Adenosine and Purinergic Signaling
Share to Epigenetics and DNA Methylation
Share to Renal Transplantation Outcomes and Treatments

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PMID: 29534238
DOI: 10.1093/ndt/gfy009

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