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Article

Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast.

Nature communications - 5 Oct 2016

Scheler Ulschan, Brandt Wolfgang, Porzel Andrea, Rothe Kathleen, Manzano David, Božić Dragana, Papaefthimiou Dimitra, Balcke Gerd Ulrich, Henning Anja, Lohse Swanhild, Marillonnet Sylvestre, Kanellis Angelos K, Ferrer Albert, Tissier Alain

Abstract excerpt

Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic acid and its reconstitution in yeast cells. Cytochrome P450 oxygenases (CYP76AH22-24) from...

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PMID: 27703160
DOI: 10.1038/ncomms12942
PMCID: PMC5059481

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