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Article

Expression, modulation, and clinical correlates of the autophagy protein Beclin‐1 in esophageal adenocarcinoma

19 Nov 2015

Abstract excerpt

Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and mortality rates and poor survival. Efficacious preventive and treatment options are urgently needed. An increasing number of pharmacologic agents targeting cancer cell death via autophagy mechanisms are being evaluated in hopes of circumventing apoptotic and therapeutic resistance. We report for the first time, loss of Beclin-1,...

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PMID: 27696537
DOI: 10.1002/mc.22432

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