Article
Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer.
Oncogene - 23 Mar 2017
Witt A E, Lee C-W, Lee T I, Azzam D J, Wang B, Caslini C, Petrocca F, Grosso J, Jones M, Cohick E B, Gropper A B, Wahlestedt C, Richardson A L, Shiekhattar R, Young R A, Ince T A
Abstract excerpt
Tumours are comprised of a highly heterogeneous population of cells, of which only a small subset of stem-like cells possess the ability to regenerate tumours in vivo. These cancer stem cells (CSCs) represent a significant clinical challenge as they are resistant to conventional cancer therapies and play essential roles in metastasis and tumour relapse. Despite this realization and great interest in CSCs, it has...
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