Article
A novel susceptibility locus at 2p24 for generalised epilepsy with febrile seizures plus.
Journal of medical genetics - 1 Dec 2005
Audenaert D, Claes L, Claeys K G, Deprez L, Van Dyck T, Goossens D, Del-Favero J, Van Paesschen W, Van Broeckhoven C, De Jonghe P
Abstract excerpt
Generalised epilepsy with febrile seizures plus (GEFS+) is a clinically and genetically heterogeneous epilepsy syndrome. Using positional cloning strategies, mutations in SCN1B, SCN1A, and GABRG2 have been identified as genetic causes of GEFS+. In the present study, we describe a large four generation family with GEFS+ in which we performed a 10 cM density genome-wide scan. We obtained conclusive evidence for a...
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