Article
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types.
Genome biology - 29 Sept 2016
Nelms Bradlee D, Waldron Levi, Barrera Luis A, Weflen Andrew W, Goettel Jeremy A, Guo Guoji, Montgomery Robert K, Neutra Marian R, Breault David T, Snapper Scott B, Orkin Stuart H, Bulyk Martha L, Huttenhower Curtis, Lencer Wayne I
Abstract excerpt
We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our method, CellMapper, strongly outperforms previous computational algorithms to predict cell type-specific expression, especially for rare and difficult-to-isolate cell types. Furthermore,...
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