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Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor

28 Oct 2017

Abstract excerpt

Aberrant expression and hyperactivation of the human epidermal growth factor receptor 2 (ErbB2) constitute crucial molecular events underpinning gastric neoplastic transformation. Despite ErbB2 extracellular domain being a well-known target for glycosylation, its glycosylation profile and the molecular mechanisms through which it actively tunes tumorigenesis in gastric cancer (GC) cells remain elusive. We aimed...

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PMID: 29143776
DOI: 10.3390/ijms18112262

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