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Article

Effect of CYP3A4 genetic polymorphisms on the genotoxicity of 4,4'-methylene-bis(2-chloroaniline)-exposed workers.

Occupational and environmental medicine - 1 Jan 2017

Wang Chung-Ching, Chen Wei-Liang, Hsiung Chia-Ni, Chiang Sheng-Ta, Wang Ying-Chuan, Loh Ching-Hui, Lin I-Shen, Chen Hong-I, Liou Saou-Hsing

Abstract excerpt

OBJECTIVES: We investigated the relationship between 4,4'-methylene-bis(2-chloroaniline) (MBOCA) exposure and micronucleus (MN) frequency, and how this association was affected by genetic polymorphism of the cytochrome P450 enzyme (CYP3A4). METHODS: We divided the study population into an exposed group (n=44 with total urine MBOCA ≥20 μg/g creatinine) and a control group (n=47 with total urine MBOCA <20 μg/g...

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PMID: 27679675
DOI: 10.1136/oemed-2016-103816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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