Article
Prime-boost therapeutic vaccination in mice with DNA/DNA or DNA/Fowlpox virus recombinants expressing the Human Papilloma Virus type 16 E6 and E7 mutated proteins fused to the coat protein of Potato virus X.
Virus research - 2 Oct 2016
Illiano Elena, Bissa Massimiliano, Paolini Francesca, Zanotto Carlo, De Giuli Morghen Carlo, Franconi Rosella, Radaelli Antonia, Venuti Aldo
Abstract excerpt
The therapeutic antitumor potency of a prime-boost vaccination strategy was explored, based on the mutated, nontransforming forms of the E6 (E6F47R) and E7 (E7GGG) oncogenes of Human Papilloma Virus type 16 (HPV16), fused to the Potato virus X (PVX) coat protein (CP) sequence. Previous data showed that CP fusion improves the immunogenicity of tumor-associated antigens and may thus increase their efficacy. After...
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