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Article

C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis

23 Sept 2016

Abstract excerpt

Introduction TheC9orf72repeat expansion has been reported as a negative prognostic factor in amyotrophic lateral sclerosis (ALS). We have examined the prognostic impact of theC9orf72repeat expansion in European subgroups based on gender and site of onset. Methods C9orf72status and demographic/clinical data from 4925 patients with ALS drawn from 3 prospective ALS registers (Ireland, Italy and the Netherlands), and...

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PMID: 27663272
DOI: 10.1136/jnnp-2016-314093

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