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Article

IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR‐Src‐MicroRNA-30a‐E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells

10 Aug 2016

Abstract excerpt

Recurrence and distant metastasis are the most common cause of therapeutic failure in nasopharyngeal carcinoma (NPC) patients. Insulin-like growth factor I (IGF-I) can induce epithelial-to-mesenchymal transition (EMT) in many epithelial tumors; however, whether IGF-I can enhance NPC metastasis by EMT and the mechanisms remain unclear. Herein, we have identified that IGF-I could induce EMT and enhance migration...

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PMID: 27656832
DOI: 10.3727/096504016x14648701447931

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