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Article

Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy

15 Sept 2016

Abstract excerpt

BACKGROUND: Identifying the subset of patients with clinically localized prostate cancer (PCa) at the highest risk of recurrence remains challenging, and better prognostic markers are needed. Gleason score is the best predictor of PCa aggressiveness and prognosis. In the present study, we generated an epigenetic signature based on high versus low Gleason score tumors and evaluated its ability to predict...

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PMID: 27651837
DOI: 10.1186/s13148-016-0260-z

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