Article
A small stem-loop structure of the Ebola virus trailer is essential for replication and interacts with heat-shock protein A8.
Nucleic acids research - 16 Nov 2016
Sztuba-Solinska Joanna, Diaz Larissa, Kumar Mia R, Kolb Gaëlle, Wiley Michael R, Jozwick Lucas, Kuhn Jens H, Palacios Gustavo, Radoshitzky Sheli R, J Le Grice Stuart F, Johnson Reed F
Abstract excerpt
Ebola virus (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family. The leader and trailer non-coding regions of the EBOV genome likely regulate its transcription, replication, and progeny genome packaging. We investigated the cis-acting RNA signals involved in RNA-RNA and RNA-protein interactions that regulate replication of eGFP-encoding EBOV minigenomic RNA and identified heat...
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