Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.

Antiviral research - 1 Oct 2016

Tarantino Delia, Cannalire Rolando, Mastrangelo Eloise, Croci Romina, Querat Gilles, Barreca Maria Letizia, Bolognesi Martino, Manfroni Giuseppe, Cecchetti Violetta, Milani Mario

Abstract excerpt

RNA dependent RNA polymerases (RdRp) are essential enzymes for flavivirus replication. Starting from an in silico docking analysis we identified a pyridobenzothiazole compound, HeE1-2Tyr, able to inhibit West Nile and Dengue RdRps activity in vitro, which proved effective against different flaviviruses in cell culture. Crystallographic data show that HeE1-2Tyr binds between the fingers domain and the priming loop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzothiazoles
Share to Crystallization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dengue Virus

Share to Drug Discovery

Share to Flavivirus

Share to Molecular Docking Simulation

Share to RNA-Dependent RNA Polymerase

Share to West Nile virus

Source

Identifiers

PMID: 27649989
DOI: 10.1016/j.antiviral.2016.09.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.PMID 27649989Read ↗

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 ReplicationSemantic proximity Read ↗

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 PolymeraseSemantic proximity Read ↗

Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indicaSemantic proximity Read ↗

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymeraseSemantic proximity Read ↗

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance ProfilingSemantic proximity Read ↗

Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infectionSemantic proximity Read ↗

A Review on the Progress and Prospects of Dengue Drug Discovery Targeting NS5 RNA- Dependent RNA PolymeraseSemantic proximity Read ↗

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitorsSemantic proximity Read ↗

Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Semantic proximity Read ↗

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral InhibitorsSemantic proximity Read ↗

N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life CycleSemantic proximity Read ↗

Searching Anti-Zika Virus Activity in 1H-1,2,3-Triazole Based CompoundsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.