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Article

Endosomal Trafficking Defects Can Induce Calcium-Dependent Azole Tolerance in Candida albicans.

Antimicrobial agents and chemotherapy - 1 Dec 2016

Luna-Tapia Arturo, Tournu Hélène, Peters Tracy L, Palmer Glen E

Abstract excerpt

The azole antifungals arrest fungal growth through inhibition of ergosterol biosynthesis. We recently reported that a Candida albicans vps21Δ/Δ mutant, deficient in membrane trafficking through the late endosome/prevacuolar compartment (PVC), continues to grow in the presence of the azoles despite the depletion of cellular ergosterol. Here, we report that the vps21Δ/Δ mutant exhibits less plasma membrane damage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27645241
DOI: 10.1128/AAC.01034-16
PMCID: PMC5118996

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