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Article

Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.

Scientific reports - 19 Sept 2016

Borgs Laurence, Peyre Elise, Alix Philippe, Hanon Kevin, Grobarczyk Benjamin, Godin Juliette D, Purnelle Audrey, Krusy Nathalie, Maquet Pierre, Lefebvre Philippe, Seutin Vincent, Malgrange Brigitte, Nguyen Laurent

Abstract excerpt

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of this mutation and its possible developmental implications, we developed an in vitro assay to model PD with human induced pluripotent stem cells (hiPSCs) reprogrammed from skin fibroblasts of PD patients suffering...

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Identifiers

PMID: 27640816
DOI: 10.1038/srep33377
PMCID: PMC5027571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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