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Article

[Pathogenetic aspects in precursor lesions of gastrointestinal tumors].

Der Pathologe - 1 Nov 2016

Rau T

Abstract excerpt

The pathogenesis of precursor lesions of gastrointestinal tumors is manifested in many ways. In the esophagus an aberrant genetic expression of intestinal transcription factors, such as CDX2 is initiated by local environment factors. During the subsequent dysplasia to carcinoma sequence, chromosomal gain and loss of genes occurs. A 4-color fluorescence in situ hybridization (FISH) assay can be applied in...

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Share to Adenomatous Polyposis Coli Protein
Share to Cell Transformation, Neoplastic
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Germ-Line Mutation

Share to In Situ Hybridization, Fluorescence

Share to Methylation

Share to Precancerous Conditions

Source

Identifiers

PMID: 27638535
DOI: 10.1007/s00292-016-0220-6

Genes

APC
BRAF
CDX1
CDX2
MLH1

Provenance

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