Article
[Molecular diagnosis of gastrointestinal cancers].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jan 1998
Yasui W, Tahara E
Abstract excerpt
Common and distinct genetic alterations are involved in the multistep mechanism of gastrointestinal carcinogenesis. Inactivation of the p53 and APC genes, activation of teleomerase and anomalous CD44 expression are common events that serve as a genetic marker for differential diagnosis of cancer. Amplification of cyclin D1 gene is preferentially found in esophageal cancer, whereas cyclin E gene amplification is...
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