Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.

doi:10.1111/andr.13009

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Article

Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.

Andrology - 1 Jul 2021

Cerván-Martín Miriam, Bossini-Castillo Lara, Rivera-Egea Rocío, Garrido Nicolás, Luján Saturnino, Romeu Gema, Santos-Ribeiro Samuel, Castilla José A, Gonzalvo María Del Carmen, Clavero Ana, Vicente Francisco Javier, Guzmán-Jiménez Andrea, Burgos Miguel, Barrionuevo Francisco Javier, Jiménez Rafael, Sánchez-Curbelo Josvany, López-Rodrigo Olga, Peraza María Fernanda, Pereira-Caetano Iris, Marques Patrícia Isabel, Carvalho Filipa, Barros Alberto, Bassas Lluís, Seixas Susana, Gonçalves João, Larriba Sara, Lopes Alexandra Manuel, Carmona Francisco David, Palomino-Morales Rogelio Jesús

Abstract excerpt

BACKGROUND: Severe spermatogenic failure (SpF) represents the most extreme manifestation of male infertility, as it decreases drastically the semen quality leading to either severe oligospermia (SO, <5 million spermatozoa/mL semen) or non-obstructive azoospermia (NOA, complete lack of spermatozoa in the ejaculate without obstructive causes). OBJECTIVES: The main objective of the present study is to analyze in the...

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PMID: 33784440
DOI: 10.1111/andr.13009

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