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Article

Changes in environmental exposures over decades may influence the genetic architecture of severe spermatogenic failure.

Human reproduction (Oxford, England) - 1 Mar 2024

Cerván-Martín Miriam, González-Muñoz Sara, Guzmán-Jiménez Andrea, Higueras-Serrano Inmaculada, Castilla José A, Garrido Nicolás, Luján Saturnino, Bassas Lluís, Seixas Susana, Gonçalves João, Lopes Alexandra M, Larriba Sara, Palomino-Morales Rogelio J, Bossini-Castillo Lara, Carmona F David

Abstract excerpt

STUDY QUESTION: Do the genetic determinants of idiopathic severe spermatogenic failure (SPGF) differ between generations? SUMMARY ANSWER: Our data support that the genetic component of idiopathic SPGF is impacted by dynamic changes in environmental exposures over decades. WHAT IS KNOWN ALREADY: The idiopathic form of SPGF has a multifactorial etiology wherein an interaction between genetic, epigenetic, and...

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Identifiers

PMID: 38305414
DOI: 10.1093/humrep/deae007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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