Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes.

doi:10.18632/oncotarget.11930

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Article

Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes.

Oncotarget - 18 Oct 2016

Mélard Pierre, Idrissi Yamina, Andrique Laetitia, Poglio Sandrine, Prochazkova-Carlotti Martina, Berhouet Sabine, Boucher Cécile, Laharanne Elodie, Chevret Edith, Pham-Ledard Anne, De Souza Góes Andréa Carla, Guyonnet-Duperat Véronique, Bibeyran Alice, Moreau-Gaudry François, Vergier Béatrice, Beylot-Barry Marie, Merlio Jean-Philippe, Cappellen David

Abstract excerpt

Monoallelic 6p25.3 rearrangements associated with DUSP22 (Dual Specificity Phosphatase 22) gene silencing have been reported in CD30+ peripheral T-cell lymphomas (PTCL), mostly with anaplastic morphology and of cutaneous origin. However, the mechanism of second allele silencing and the putative tumor suppressor function of DUSP22 have not been investigated so far. Here, we show that the presence, in most...

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Identifiers

PMID: 27626696
DOI: 10.18632/oncotarget.11930
PMCID: PMC5356586

Genes

DUSP22

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Source receipt: pubmed, retrieved 6 Sept 2026.

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