Article
The Depressed Frail Phenotype: The Clinical Manifestation of Increased Biological Aging.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Nov 2016
Brown Patrick J, Rutherford Bret R, Yaffe Kristine, Tandler Jane M, Ray Justina Laurence, Pott Emily, Chung Sarah, Roose Steven P
Abstract excerpt
Depression in later life is a severe public health problem, associated with higher rates of mortality, suicide, and dementia. Effectiveness of treatment is limited by the failure to deconstruct the heterogeneity of the illness and because diagnostic criteria, pathophysiological models, and treatment algorithms for depression are primarily based on studies of younger adults even though symptoms of the illness and...
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