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Article

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

27 Jul 2022

Abstract excerpt

Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse fetal outcomes. Several studies have indicated that ZIKV can damage the fetal brain directly; however, whether the ZIKV-induced maternal placental injury contributes to adverse fetal outcomes is sparsely defined. Here, we demonstrated that ZIKV causes the pyroptosis of placental cells by activating the executor gasdermin E...

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PMID: 35972780
DOI: 10.7554/elife.73792

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