Article
Genomic analysis of 495 vancomycin-resistant Enterococcus faecium reveals broad dissemination of a vanA plasmid in more than 19 clones from Copenhagen, Denmark.
The Journal of antimicrobial chemotherapy - 1 Jan 2017
Pinholt Mette, Gumpert Heidi, Bayliss Sion, Nielsen Jesper B, Vorobieva Veronika, Pedersen Michael, Feil Edward, Worning Peder, Westh Henrik
Abstract excerpt
OBJECTIVES: From 2012 to 2014, there has been a huge increase in vancomycin-resistant (vanA) Enterococcus faecium (VREfm) in Copenhagen, Denmark, with 602 patients infected or colonized with VREfm in 2014 compared with just 22 in 2012. The objective of this study was to describe the genetic epidemiology of VREfm to assess the contribution of clonal spread and horizontal transfer of the vanA transposon (Tn1546)...
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