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Article

MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells

5 Sept 2016

Abstract excerpt

BACKGROUND: In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs). METHODS: We first used a computational target prediction analysis to identify 6 candidate miRNAs that bind to the 3'-untranslated region...

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PMID: 27596137
DOI: 10.1186/s13046-016-0415-y

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Related research

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Research trail→

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MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cellsPMID 27596137Read ↗

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MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancerSemantic proximity Read ↗

ALX1 Induces Snail Expression to Promote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer CellsSemantic proximity Read ↗

MicroRNA-136 functions as a tumor suppressor in osteosarcoma via regulating metadherinSemantic proximity Read ↗

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