Article
A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer.
Oncogene - 5 Jan 2017
Selth L A, Das R, Townley S L, Coutinho I, Hanson A R, Centenera M M, Stylianou N, Sweeney K, Soekmadji C, Jovanovic L, Nelson C C, Zoubeidi A, Butler L M, Goodall G J, Hollier B G, Gregory P A, Tilley W D
Abstract excerpt
MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely correlated with epithelial-mesenchymal transition signatures (EMT) in clinical samples and can drive mesenchymal-epithelial transition (MET) in model systems. Indeed,...
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