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Impact of the RNA allosteric effect triggered by single nucleotide polymorphisms on the splicing process.

Human molecular genetics - 19 Jun 2023

Zhuang Youyuan, Lu Xiaoyan, Lin Peng, Wang Siyu, Sheng Xiaoran, Chen Chong, Zhang Guosi, Wang Zhiyi, Mei Changqiu, Qu Jia, Xu Liangde, Wang Hong

Abstract excerpt

The susceptibility single nucleotide polymorphisms (SNPs) obtained by genome-wide association studies leave some thorny questions, such as prioritization, false positives and unknown pathogenesis. Previous studies suggested that genetic variation may perturb the RNA secondary structure, influence protein recruitment and binding and ultimately affect splicing processes. Therefore, exploring the perturbation of...

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PMID: 37017337
DOI: 10.1093/hmg/ddad057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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