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Article

Nonstructural Proteins Are Preferential Positive Selection Targets in Zika Virus and Related Flaviviruses

2 Sept 2016

Abstract excerpt

The Flavivirus genus comprises several human pathogens such as dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV). Although ZIKV usually causes mild symptoms, growing evidence is linking it to congenital birth defects and to increased risk of Guillain-Barré syndrome. ZIKV encodes a polyprotein that is processed to produce three structural and seven nonstructural (NS) proteins. We...

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PMID: 27588756
DOI: 10.1371/journal.pntd.0004978

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