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Article

Treatment of renal angiomyolipoma in tuberous sclerosis complex (TSC) patients.

Pediatric nephrology (Berlin, Germany) - 1 Jul 2017

Brakemeier S, Bachmann F, Budde K

Abstract excerpt

In adult tuberous sclerosis complex (TSC) patients, renal complications are the leading cause of death. Beginning in childhood, up to 80 % of patients develop renal angiomyolipoma characterized by a size-dependent risk of life-threatening bleeding. After discovery of the two causative genes, TSC1 and TSC2, and the role of mammalian target of rapamycin (mTOR) regulation in the pathogenesis of TSC, an increasing...

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Source

Identifiers

PMID: 27585680
DOI: 10.1007/s00467-016-3474-6

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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