Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula.

doi:10.1038/srep32513

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Article

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula.

Scientific reports - 1 Sept 2016

Sazzini Marco, Gnecchi Ruscone Guido Alberto, Giuliani Cristina, Sarno Stefania, Quagliariello Andrea, De Fanti Sara, Boattini Alessio, Gentilini Davide, Fiorito Giovanni, Catanoso Mariagrazia, Boiardi Luigi, Croci Stefania, Macchioni Pierluigi, Mantovani Vilma, Di Blasio Anna Maria, Matullo Giuseppe, Salvarani Carlo, Franceschi Claudio, Pettener Davide, Garagnani Paolo, Luiselli Donata

Abstract excerpt

The Italian peninsula has long represented a natural hub for human migrations across the Mediterranean area, being involved in several prehistoric and historical population movements. Coupled with a patchy environmental landscape entailing different ecological/cultural selective pressures, this might have produced peculiar patterns of population structure and local adaptations responsible for heterogeneous...

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PMID: 27582244
DOI: 10.1038/srep32513
PMCID: PMC5007512

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