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Article

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

30 Aug 2016

Abstract excerpt

Epigenetic modifications are essential regulators of biological processes. Decreased DNA methylation of OAS2 (2'-5'-Oligoadenylate Synthetase 2), encoding an antiviral protein, has been seen in psoriasis. To provide further insight into the epigenetic regulation of OAS2, we performed pyrosequencing to detect OAS2 DNA methylation status at 11 promoter and first exon located CpG sites in psoriasis (n = 12) and two...

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PMID: 27572959
DOI: 10.1038/srep32579

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