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Article

Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines.

Scientific reports - 30 Aug 2016

Gotanda Keisuke, Hirota Takeshi, Saito Jumpei, Fukae Masato, Egashira Yu, Izumi Noritomo, Deguchi Mariko, Kimura Miyuki, Matsuki Shunji, Irie Shin, Ieiri Ichiro

Abstract excerpt

A variant in the breast cancer resistance protein (BCRP) gene, 421C> A is a useful biomarker for describing large inter-individual differences in the pharmacokinetics of sulfasalazine (SASP), a BCRP substrate. However, large intra-genotypic variability still exists in spite of the incorporation of this variant into the pharmacokinetics of SASP. Since miR-328 negatively regulates BCRP expression in human tissues,...

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Identifiers

PMID: 27571936
DOI: 10.1038/srep32299
PMCID: PMC5004159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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