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Fusion between cancer cells and macrophages occurs in a murine model of spontaneous neu+ breast cancer without increasing its metastatic potential.

Oncotarget - 20 Sept 2016

Lizier Michela, Anselmo Achille, Mantero Stefano, Ficara Francesca, Paulis Marianna, Vezzoni Paolo, Lucchini Franco, Pacchiana Giovanni

Abstract excerpt

Cell fusion between neoplastic and normal cells has been suggested to play a role in the acquisition of a malignant phenotype. Several studies have pointed to the macrophage as the normal partner in this fusion, suggesting that the fused cells could acquire new invasive properties and become able to disseminate to distant organs. However, this conclusion is mainly based on studies with transplantable cell lines....

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Identifiers

PMID: 27563823
DOI: 10.18632/oncotarget.11508
PMCID: PMC5308617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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