Article
Trivalency of a Nanobody Specific for the Human Respiratory Syncytial Virus Fusion Glycoprotein Drastically Enhances Virus Neutralization and Impacts Escape Mutant Selection.
Antimicrobial agents and chemotherapy - 1 Nov 2016
Palomo Concepción, Mas Vicente, Detalle Laurent, Depla Erik, Cano Olga, Vázquez Mónica, Stortelers Catelijne, Melero José A
Abstract excerpt
ALX-0171 is a trivalent Nanobody derived from monovalent Nb017 that binds to antigenic site II of the human respiratory syncytial virus (hRSV) fusion (F) glycoprotein. ALX-0171 is about 6,000 to 10,000 times more potent than Nb017 in neutralization tests with strains of hRSV antigenic groups A and B. To explore the effect of this enhanced neutralization on escape mutant selection, viruses resistant to either...
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