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Article

The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity

1 Aug 2016

Abstract excerpt

Metabolically healthy obese subjects display preserved insulin sensitivity and a beneficial white adipose tissue gene expression pattern. However, this observation stems from fasting studies when insulin levels are low. We investigated adipose gene expression by 5'Cap-mRNA sequencing in 17 healthy non-obese (NO), 21 insulin-sensitive severely obese (ISO), and 30 insulin-resistant severely obese (IRO) subjects,...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 27545890
DOI: 10.1016/j.celrep.2016.07.070

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