Article
Low Gene Dosage of Cdc42 Is Not Associated with Protein Dysfunction in Patients with Colorectal Cancer.
DNA and cell biology - 1 Dec 2016
González-Quiroz Matías, Calderón Ximena, Oyarzún Ingrid, Hoepfner Claudia, Azócar Andrés, Aguirre Adam, Álvarez Karin, Quera Rodrigo, López-Köstner Francisco, Meléndez Jaime
Abstract excerpt
High incidence of Rho Cdc42-GTPase overexpression has been found in Colorectal Cancer (CRC) samples, suggesting its potential role in tumor development. However, no conclusive studies have shown the lack of mutations and/or copy number of Cdc42 gene in this type of samples. To understand mutation/deletion and copy number status of Cdc42 gene, CRC patients were evaluated for both parameters. More than Cdc42...
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