Article
Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse.
Oncotarget - 30 Aug 2016
Corvaisier Matthieu, Bauzone Marjolaine, Corfiotti François, Renaud Florence, El Amrani Mehdi, Monté Didier, Truant Stéphanie, Leteurtre Emmanuelle, Formstecher Pierre, Van Seuningen Isabelle, Gespach Christian, Huet Guillemette
Abstract excerpt
Our aim was to decipher the role and clinical relevance of the YAP/TAZ transcriptional coactivators in the regulation of the proliferation/quiescence balance in human colon cancer cells (CCC) and survival after 5FU-based chemotherapy. The prognostic value of YAP/TAZ on tumor relapse and overall survival was assessed in a five-year follow-up study using specimens of liver metastases (n = 70) from colon cancer...
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