Article
Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer.
Archives of oral biology - 1 Dec 2016
Chen Hung-Chih, Tseng Yu-Kai, Chi Chao-Chuan, Chen Yu-Hung, Yang Cheng-Mei, Huang Sin-Jhih, Lee Yi-Cheng, Liou Huei-Han, Tsai Kuo-Wang, Ger Luo-Ping
Abstract excerpt
OBJECTIVE: To investigate the relationships between two single-nucleotide polymorphisms at miR-146a C>G (rs2910164) and miR-1269b G>C (rs7210937) and the risk of developing oral premalignant lesions (OPLs), oral squamous cell carcinoma (OSCC), pharyngeal SCC (PSCC), and oral and pharyngeal SCC (OPSCC). DESIGN: Genotyping of miR-146a C>G and miR-1269b G>C was performed in two case-control studies using the TaqMan...
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