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Article

APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway

1 Jul 2016

Abstract excerpt

Accumulation of amyloid-β (Aβ) peptide in the brain is a central hallmark of Alzheimer's disease (AD) and is thought to be the cause of the observed neurodegeneration. Many animal models have been generated that overproduce Aβ yet do not exhibit clear neuronal loss, questioning this Aβ hypothesis. We previously developed an in vivo mouse model that expresses a humanized amyloid precursor protein (hAPP) in...

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PMID: 27517085
DOI: 10.1523/eneuro.0150-16.2016

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