A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia

Abstract excerpt

Idiopathic trigeminal neuralgia (TN) is a debilitating pain disorder characterized by episodic unilateral facial pain along the territory of branches of the trigeminal nerve. Human pain disorders, but not TN, have been linked to gain-of-function mutations in peripheral voltage-gated sodium channels (Na V 1.7, Na V 1.8 and Na V 1.9). Gain-of-function mutations in Na V 1.6, which is expressed in myelinated and...

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