Article
An RNA conformational shift in recent H5N1 influenza A viruses.
Bioinformatics (Oxford, England) - 1 Feb 2007
Gultyaev Alexander P, Heus Hans A, Olsthoorn René C L
Abstract excerpt
UNLABELLED: Recent outbreaks of avian influenza are being caused by unusually virulent H5N1 strains. It is unknown what makes these recent H5N1 strains more aggressive than previously circulating strains. Here, we have compared more than 3000 RNA sequences of segment 8 of type A influenza viruses and found a unique single nucleotide substitution typically associated with recent H5N1 strains. By phylogenetic...
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