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Article

Coexistence of JAK2 and CALR mutations and their clinical implications in patients with essential thrombocythemia.

Oncotarget - 30 Aug 2016

Kang Min-Gu, Choi Hyun-Woo, Lee Jun Hyung, Choi Yong Jun, Choi Hyun-Jung, Shin Jong-Hee, Suh Soon-Pal, Szardenings Michael, Kim Hye-Ran, Shin Myung-Geun

Abstract excerpt

Janus kinase 2 (JAK2) and calreticulin (CALR) constitute the two most frequent mutations in essential thrombocythemia (ET), and both are reported to be mutually exclusive. Hence, we examined a cohort of 123 myeloproliferative neoplasm (MPN) patients without BCR-ABL1 rearrangement and additional ET patients (n=96) for coexistence of JAK2 and CALR mutations. The frequency of CALR mutations was 20.3% in 123 MPN...

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Source

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Identifiers

PMID: 27486987
DOI: 10.18632/oncotarget.10958
PMCID: PMC5302971

Genes

CALR
JAK2
ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Coexistence of JAK2 and CALR mutations and their clinical implications in patients with essential thrombocythemia.PMID 27486987Read ↗

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