Article
Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study.
Oncotarget - 20 Sept 2016
Coppola Nicola, Onorato Lorenzo, Iodice Valentina, Starace Mario, Minichini Carmine, Farella Nunzia, Liorre Giulia, Filippini Pietro, Sagnelli Evangelista, de Stefano Giorgio
Abstract excerpt
AIM: To evaluate the virological and clinical characteristics of occult HBV infection (OBI) in 68 consecutive HBsAg-negative patients with biopsy-proven cirrhosis and HCC. METHODS: HBV DNA was sought and sequenced in plasma, HCC tissue and non-HCC liver tissue by PCRs using primers for HBV core, surface and x regions. OBI was identified by the presence of HBV DNA in at least two different PCRs. RESULTS: OBI was...
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