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Article

Association between IRS1 Gene Polymorphism and Autism Spectrum Disorder: A Pilot Case-Control Study in Korean Males.

International journal of molecular sciences - 29 Jul 2016

Park Hae Jeong, Kim Su Kang, Kang Won Sub, Park Jin Kyung, Kim Young Jong, Nam Min, Kim Jong Woo, Chung Joo-Ho

Abstract excerpt

The insulin-like growth factor (IGF) pathway is thought to play an important role in brain development. Altered levels of IGFs and their signaling regulators have been shown in autism spectrum disorder (ASD) patients. In this study, we investigated whether coding region single-nucleotide polymorphisms (cSNPs) of the insulin receptor substrates (IRS1 and IRS2), key mediators of the IGF pathway, were associated...

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Source

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Identifiers

PMID: 27483248
DOI: 10.3390/ijms17081227
PMCID: PMC5000625

Genes

IRS1
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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