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Article

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24.

Journal of clinical immunology - 1 Oct 2016

Daschkey Svenja, Bienemann Kirsten, Schuster Volker, Kreth Hans Wolfgang, Linka René Martin, Hönscheid Andrea, Fritz Gerhard, Johannes Christian, Fleckenstein Bernhard, Kempkes Bettina, Gombert Michael, Ginzel Sebastian, Borkhardt Arndt

Abstract excerpt

Hereditary defects in several genes have been shown to disturb the normal immune response to EBV and to give rise to severe EBV-induced lymphoproliferation in the recent years. Nevertheless, in many patients, the molecular basis of fatal EBV infection still remains unclear. The Fanconi anemia-associated protein 24 (FAAP24) plays a dual role in DNA repair. By association with FANCM as component of the FA core...

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Source

Identifiers

PMID: 27473539
DOI: 10.1007/s10875-016-0317-y

Genes

FAAP24
ATR
FANCD2
FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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