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Article

Late-onset severe chronic active EBV in a patient for five years with mutations in STXBP2 (MUNC18-2) and PRF1 (perforin 1).

Journal of clinical immunology - 1 Jul 2015

Cohen Jeffrey I, Niemela Julie E, Stoddard Jennifer L, Pittaluga Stefania, Heslop Helen, Jaffe Elaine S, Dowdell Kennichi

Abstract excerpt

Severe chronic active Epstein-Barr virus (CAEBV) disease is defined as a severe progressive illness lasting 6 months or longer with infiltration of tissues with EBV-positive lymphocytes, markedly elevated levels of EBV DNA in the blood, and no known immunodeficiency such as HIV. These patients us...

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Share to Bone Marrow Transplantation
Share to Cytotoxicity, Immunologic
Share to Epstein-Barr Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Lysosomal-Associated Membrane Protein 1

Share to Munc18 Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 25947952
DOI: 10.1007/s10875-015-0168-y
PMCID: PMC4504756

Genes

PRF1
STXBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25947952-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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